Synthesis and anti-HIV activities of symmetrical N1,N3-dibenzyl-2-hydroxy-propane derivatives

M Medou; M Bouygues; L Rocheblave; J C Chermann; J L Kraus

doi:10.1016/s0960-894x(98)00323-0

Synthesis and anti-HIV activities of symmetrical N1,N3-dibenzyl-2-hydroxy-propane derivatives

Bioorg Med Chem Lett. 1998 Jul 21;8(14):1861-6. doi: 10.1016/s0960-894x(98)00323-0.

Authors

M Medou¹, M Bouygues, L Rocheblave, J C Chermann, J L Kraus

Affiliation

¹ Laboratoire de Chimie Biomoléculaire, Faculté des Sciences de Luminy, Université de la Méditerranée, Marseille.

PMID: 9873448
DOI: 10.1016/s0960-894x(98)00323-0

Abstract

We report the synthesis and the anti-HIV activities of new C2-symmetrical and achiral N1,N3-dibenzyl-2-hydroxy-propane isosteres. Some of them showed significant inhibitory activity with respect to HIV-infected MT4 cells (compound 6a and 7a, IC50 = 0.1 microM). These new structurally simple compounds represent new synthons which can be suitable for combinatorial chemistry purposes.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-HIV Agents / chemical synthesis*
Anti-HIV Agents / chemistry
Anti-HIV Agents / pharmacology*
Benzylamines / chemical synthesis*
Benzylamines / chemistry
Benzylamines / pharmacology*
Cell Line
Humans
Propanolamines / chemical synthesis*
Propanolamines / chemistry
Propanolamines / pharmacology*
Structure-Activity Relationship

Substances

Anti-HIV Agents
Benzylamines
Propanolamines